Mouse models and strain-dependency of Chédiak-Higashi syndrome-associated neurologic dysfunction

Chédiak-Higashi syndrome (CHS) is a lethal disorder caused by mutations in the LYST gene that involves progressive neurologic dysfunction. Lyst-mutant mice exhibit neurologic phenotypes that are sensitive to genetic background. On the DBA/2J-, but not on the C57BL/6J-background, Lyst-mutant mice exh...

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Publicado no:Sci Rep
Main Authors: Hedberg-Buenz, Adam, Dutca, Laura M., Larson, Demelza R., Meyer, Kacie J., Soukup, Dana A., van der Heide, Carly J., Mercer, Hannah E., Wang, Kai, Anderson, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494809/
https://ncbi.nlm.nih.gov/pubmed/31043676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42159-0
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