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Activated protein C inhibits LPS-mediated acetylation and secretion of HMGB1 in endothelial cells

BACKGROUND: Activated protein C (APC) inhibits high mobility group box 1 (HMGB1) signaling and its LPS-mediated release by EPCR-dependent activation of PAR1 in endothelial cells. Post-translational acetylation is known to modulate the subcellular localization of HMGB1 and its hyperacetylated form is...

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Bibliografske podrobnosti
izdano v:J Thromb Haemost
Main Authors: Cai, Xiaofeng, Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Rezaie, Alireza R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494677/
https://ncbi.nlm.nih.gov/pubmed/30865333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14425
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