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Activated protein C inhibits LPS-mediated acetylation and secretion of HMGB1 in endothelial cells
BACKGROUND: Activated protein C (APC) inhibits high mobility group box 1 (HMGB1) signaling and its LPS-mediated release by EPCR-dependent activation of PAR1 in endothelial cells. Post-translational acetylation is known to modulate the subcellular localization of HMGB1 and its hyperacetylated form is...
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| Udgivet i: | J Thromb Haemost |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494677/ https://ncbi.nlm.nih.gov/pubmed/30865333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14425 |
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