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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

As the first structural elucidation of a modular polyketide synthase (PKS) domain, the crystal structure of the macrocycle-forming thioesterase (TE) domain from the 6-deoxyerythronolide B synthase (DEBS) was solved by a combination of multiple isomorphous replacement and multiwavelength anomalous di...

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Gespeichert in:
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tsai, Shiou-Chuan, Miercke, Larry J. W., Krucinski, Jolanta, Gokhale, Rajesh, Chen, Julian C.-H., Foster, Paul G., Cane, David E., Khosla, Chaitan, Stroud, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64940/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752428/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.011399198
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