Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance

BACKGROUND: Protein-bound uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) have been associated with cardiovascular morbidity and mortality in patients with CKD. However, direct evidence for a role of these toxins in CKD-related vascular calcification has not been reported. METHODS: To...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Opdebeeck, Britt, Maudsley, Stuart, Azmi, Abdelkrim, De Maré, Annelies, De Leger, Wout, Meijers, Bjorn, Verhulst, Anja, Evenepoel, Pieter, D’Haese, Patrick C., Neven, Ellen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493976/
https://ncbi.nlm.nih.gov/pubmed/30940651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018060609
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