Thrombospondin Type 1 Domain–Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes

BACKGROUND: About 3%–5% of adults with membranous nephropathy have autoantibodies directed against thrombospondin type 1 domain–containing 7A (THSD7A), a podocyte-expressed transmembrane protein. However, the temporal and spatial expression of THSD7A and its biologic function for podocytes are unkno...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Herwig, Johanna, Skuza, Sinah, Sachs, Wiebke, Sachs, Marlies, Failla, Antonio Virgilio, Rune, Gabriele, Meyer, Tobias N., Fester, Lars, Meyer-Schwesinger, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493974/
https://ncbi.nlm.nih.gov/pubmed/30971456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018090941
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