Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase‐3β Signaling Pathway in an Alzheimer's Disease Model

AIM: Tau hyperphosphorylation and amyloid β‐peptide overproduction, caused by altered localization or abnormal activation of glycogen synthase kinase‐3β (GSK‐3β), is a pathogenic mechanism in Alzheimer's disease (AD). Valproic acid (VPA) attenuates senile plaques and neuronal loss. Here, we con...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Long, Zhi‐Min, Zhao, Lei, Jiang, Rong, Wang, Ke‐Jian, Luo, Shi‐Fang, Zheng, Min, Li, Xiao‐Feng, He, Gui‐Qiong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493017/
https://ncbi.nlm.nih.gov/pubmed/26385876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12445
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