Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer

Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional immune infiltrate able to recognize tumor mutated antigens, or neoantigens. Although patient-derived xenografts (PDXs) can partially model the tumor mutational load and mimic response to chemotherapy, no study...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Want, Muzamil Yaqub, Konstorum, Anna, Huang, Ruea-Yea, Jain, Vaibhav, Matsueda, Satoko, Tsuji, Takemasa, Lugade, Amit, Odunsi, Kunle, Koya, Richard, Battaglia, Sebastiano
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2019
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492964/
https://ncbi.nlm.nih.gov/pubmed/31069153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1586042
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