Neuronal Soluble Fas Ligand Drives M1‐Microglia Polarization after Cerebral Ischemia

AIMS: This study explored sFasL expression in neurons and the potential role of neuronal sFasL in modulating the microglial phenotypes. METHODS: In vivo, middle cerebral artery occlusion (MCAO) was induced in both FasL‐mutant (gld) and wild‐type (wt) mice. In vitro, primary cortical neuron or microg...

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Pubblicato in:CNS Neurosci Ther
Autori principali: Meng, Hai‐Lan, Li, Xiao‐Xi, Chen, Yan‐Ting, Yu, Lin‐Jie, Zhang, He, Lao, Jia‐Min, Zhang, Xin, Xu, Yun
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492913/
https://ncbi.nlm.nih.gov/pubmed/27283206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12575
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