Claudin‐5 regulates blood‐brain barrier permeability by modifying brain microvascular endothelial cell proliferation, migration, and adhesion to prevent lung cancer metastasis

AIMS: To investigate the roles of Claudin‐5 (CLDN5) in regulating the permeability of the blood‐brain barrier (BBB) during lung cancer brain metastasis. RESULTS: By silencing and overexpressing the CLDN5 gene in human brain vascular endothelial (hCMEC/D3) cells, we demonstrated the attenuation of ce...

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Detalles Bibliográficos
Publicado en:CNS Neurosci Ther
Main Authors: Ma, Shun‐Chang, Li, Qi, Peng, Jia‐Yi, Zhouwen, Jian‐Long, Diao, Jin‐Fu, Niu, Jian‐Xing, Wang, Xi, Guan, Xiu‐Dong, Jia, Wang, Jiang, Wen‐Guo
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492739/
https://ncbi.nlm.nih.gov/pubmed/28961379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12764
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