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Cytome micronucleus assays with a metabolically competent human derived liver cell line (Huh6): A promising approach for routine testing of chemicals?

One of the main problems of in vitro genotoxicity tests is the inadequate representation of drug metabolizing enzymes in most indicator cell lines which are currently used. We identified recently a human derived liver cell line (Huh6) which detected induction of DNA damage by representatives of diff...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Environ Mol Mutagen
Prif Awduron: Mišík, Miroslav, Nersesyan, Armen, Bolognesi, Claudia, Kundi, Michael, Ferk, Franziska, Knasmueller, Siegfried
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons, Inc. 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492180/
https://ncbi.nlm.nih.gov/pubmed/30408237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22254
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