Hydrogen‐Bond‐Enabled Dynamic Kinetic Resolution of Axially Chiral Amides Mediated by a Chiral Counterion

Non‐biaryl atropisomers are valuable in medicine, materials, and catalysis, but their enantioselective synthesis remains a challenge. Herein, a counterion‐mediated O‐alkylation method for the generation of atropisomeric amides with an er up to 99:1 is outlined. This dynamic kinetic resolution is ena...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Fugard, Alison J., Lahdenperä, Antti S. K., Tan, Jaqueline S. J., Mekareeya, Aroonroj, Paton, Robert S., Smith, Martin D.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492105/
https://ncbi.nlm.nih.gov/pubmed/30644159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201814362
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