Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia

BACKGROUND: Apoptosis-stimulating Protein of TP53-2 (ASPP2) is a tumor suppressor enhancing TP53-mediated apoptosis via binding to the TP53 core domain. TP53 mutations found in cancers disrupt ASPP2 binding, arguing for an important role of ASPP2 in TP53-mediated tumor suppression. We now identify a...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Schittenhelm, Marcus Matthias, Walter, Bianca, Tsintari, Vasileia, Federmann, Birgit, Bajrami Saipi, Mihada, Akmut, Figen, Illing, Barbara, Mau-Holzmann, Ulrike, Fend, Falko, Lopez, Charles Darin, Kampa-Schittenhelm, Kerstin Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491939/
https://ncbi.nlm.nih.gov/pubmed/30952616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.028
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