Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin

The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NASH with or without the treatment of ma...

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Publicado en:Front Pharmacol
Autores principales: Mahzari, Ali, Li, Songpei, Zhou, Xiu, Li, Dongli, Fouda, Sherouk, Alhomrani, Majid, Alzahrani, Wala, Robinson, Stephen R., Ye, Ji-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491841/
https://ncbi.nlm.nih.gov/pubmed/31068812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00405
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