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Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs

CD137 ligand-induced dendritic cells (CD137L-DCs) are a new type of dendritic cells (DCs) that induce strong cytotoxic T cell responses. Investigating the metabolic activity as a potential contributing factor for their potency, we find a significantly higher rate of glycolysis in CD137L-DCs than in...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Zeng, Qun, Mallilankaraman, Karthik, Schwarz, Herbert
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491642/
https://ncbi.nlm.nih.gov/pubmed/31068941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00868
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