Intra-Familial Phenotypic Heterogeneity and Telomere Abnormality in von Hippel- Lindau Disease: Implications for Personalized Surveillance Plan and Pathogenesis of VHL-Associated Tumors

von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome with poor survival. The current recommendations have proposed uniform surveillance strategies for all patients, neglecting the obvious phenotypic varieties. In this study, we aim to confirm the phenotypic heterogeneity in VHL disease an...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Wang, Jiangyi, Peng, Xiang, Chen, Cen, Ning, Xianghui, Peng, Shuanghe, Li, Teng, Liu, Shengjie, Hong, Baoan, Zhou, Jingcheng, Ma, Kaifang, Cai, Lin, Gong, Kan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491623/
https://ncbi.nlm.nih.gov/pubmed/31068970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00358
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