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Characterization of the Phosphorylation Site of GRTH/DDX25 and Protein Kinase A Binding Interface Provides Structural Basis for the Design of a Non-Hormonal Male Contraceptive

Gonadotropin Regulated Testicular Helicase (GRTH/DDX25), expressed in the male gonad, is essential for the completion of spermatogenesis. Our early studies revealed a missense mutation (R242H) of GRTH in 5.8% of Japanese patient population with azoospermia. Transfection of the mutant GRTH construct...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Raju, Murugananthkumar, Hassan, Sergio A., Kavarthapu, Raghuveer, Anbazhagan, Rajakumar, Dufau, Maria L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491591/
https://ncbi.nlm.nih.gov/pubmed/31040297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42857-9
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