The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

Lysosomal replacement enzymes are essential therapeutic options for rare congenital lysosomal enzyme deficiencies, but enzymes in clinical use are only partially effective due to short circulatory half-life and inefficient biodistribution. Replacement enzymes are primarily taken up by cell surface g...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tian, Weihua, Ye, Zilu, Wang, Shengjun, Schulz, Morten Alder, Van Coillie, Julie, Sun, Lingbo, Chen, Yen-Hsi, Narimatsu, Yoshiki, Hansen, Lars, Kristensen, Claus, Mandel, Ulla, Bennett, Eric Paul, Jabbarzadeh-Tabrizi, Siamak, Schiffmann, Raphael, Shen, Jin-Song, Vakhrushev, Sergey Y., Clausen, Henrik, Yang, Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491494/
https://ncbi.nlm.nih.gov/pubmed/31040271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09809-3
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