Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

BACKGROUND: Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical “don't find me” signal to the adaptive immune system. Equally CD47 is a critical “don't eat me” sign...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Lian, Shu, Xie, Ruizhi, Ye, Yuying, Xie, Xiaodong, Li, Shuhui, Lu, Yusheng, Li, Bifei, Cheng, Yunlong, Katanaev, Vladimir L., Jia, Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491392/
https://ncbi.nlm.nih.gov/pubmed/30878596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.018
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