Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer’s disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of most...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Koelewijn, Loes, Lancaster, Thomas M, Linden, David, Dima, Diana C, Routley, Bethany C, Magazzini, Lorenzo, Barawi, Kali, Brindley, Lisa, Adams, Rachael, Tansey, Katherine E, Bompas, Aline, Tales, Andrea, Bayer, Antony, Singh, Krish
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491037/
https://ncbi.nlm.nih.gov/pubmed/31038453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36011
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