The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB

SAMHD1 is a human restriction factor known to prevent infection of macrophages, resting CD4(+) T cells, and dendritic cells by HIV-1. To test the contribution of MxB to the ability of SAMHD1 to block HIV-1 infection, we created human THP-1 cell lines that were knocked out for expression of MxB, SAMH...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Buffone, Cindy, Kutzner, Juliane, Opp, Silvana, Martinez-Lopez, Alicia, Selyutina, Anastasia, Ana Coggings, Si, Studdard, Lydia R., Ding, Lingmei, Kim, Baek, Spearman, Paul, Schaller, Torsten, Diaz-Griffero, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487861/
https://ncbi.nlm.nih.gov/pubmed/30959264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.03.018
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