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Potential Applications of NRF2 Inhibitors in Cancer Therapy

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors. Indeed, by increasing the expression of several cytoprotective genes, the transcription factor NRF2 can shelter cells and tissues from multiple sources of damage including x...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Panieri, Emiliano, Saso, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487091/
https://ncbi.nlm.nih.gov/pubmed/31097977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/8592348
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