Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes

We recently reported that myeloid cell-expressed sirtuin 6 (Sirt6) plays a crucial role in M1 macrophage polarization and chemotaxis. Given the prominent role of macrophages during wound repair and macrophage heterogeneity, we hypothesized that a Sirt6 deficiency in myeloid cells would delay skin wo...

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Bibliographic Details
Published in:Exp Mol Med
Main Authors: Koo, Jeung-Hyun, Jang, Hyun-Young, Lee, Youngyi, Moon, Young Jae, Bae, Eun Ju, Yun, Seok-Kweon, Park, Byung-Hyun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486573/
https://ncbi.nlm.nih.gov/pubmed/31028245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0248-9
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