Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

BACKGROUND. Systems vaccinology allows cutting-edge analysis of innate biomarkers of vaccine efficacy. We explored a strategy to shape the adaptive immune response by targeting innate immune cells through novel immunization routes. METHODS. This randomized phase I/II clinical study (n = 60 healthy s...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gonçalves, Eléna, Bonduelle, Olivia, Soria, Angèle, Loulergue, Pierre, Rousseau, Alexandra, Cachanado, Marine, Bonnabau, Henri, Thiebaut, Rodolphe, Tchitchek, Nicolas, Behillil, Sylvie, van der Werf, Sylvie, Vogt, Annika, Simon, Tabassome, Launay, Odile, Combadière, Behazine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486343/
https://ncbi.nlm.nih.gov/pubmed/30843873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125372
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