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Davis–Beirut Reaction: Alkoxide versus Hydroxide Addition to the Key o-Nitrosoimine Intermediate

Reaction options, alkoxide vs hydroxide vs amine addition to the key intermediate (o-nitrosoimine) generated in the Davis–Beirut reaction of an o-nitrobenzyl-amine substrate, are reported to explain the nucleophilic addition selectivity of this one-pot indazole-forming process. The hydroxide additio...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Zhu, Jie S., Duong, Matthew R., Teuthorn, Andrew P., Lu, Julia Y., Son, Jung-Ho, Haddadin, Makhluf J., Kurth, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485925/
https://ncbi.nlm.nih.gov/pubmed/29431446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b00036
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