In vivo targeting of protein antigens to dendritic cells using anti‐DEC‐205 single chain antibody improves HIV Gag specific CD4(+) T cell responses protecting from airway challenge with recombinant vaccinia‐gag virus

INTRODUCTION: Targeting antigens to dendritic cells (DCs) in vivo via a DC‐restricted endocytic receptor, DEC205, has been validated to enhance immunity in several vaccine platforms. Particularly atttractive is selected delivery of proteins to DCs in vivo because it enables proteins to be more immun...

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Vydáno v:Immun Inflamm Dis
Hlavní autoři: Ngu, Loveline N., Nji, Nadesh N., Ambada, Georgia E., Sagnia, Bertrand, Sake, Carol Ngane, Tchadji, Jules Colinc, Njambe Priso, Ghislain Donald, Lissom, Abel, Tchouangueu, Thibau Flaurant, Manga Tebit, Denis, Waffo, Alain Bopda, Park, Chae Gyu, Steinman, Ralph M., Überla, Klaus, Nchinda, Godwin W.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485703/
https://ncbi.nlm.nih.gov/pubmed/28474788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.151
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