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Synthesis and in vitro characterization of entirely S-protected thiolated pectin for drug delivery

The study was aimed to synthesize a thiolated polymer (thiomer) that is resistant to oxidation in solutions above pH 5. In order to protect a pectin-cysteine conjugate against premature oxidation, the thiomer was S-protected by a disulfide connected leaving group. Therefore, 2-mercaptonicotinic acid...

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Detalhes bibliográficos
Publicado no:Eur J Pharm Biopharm
Main Authors: Hintzen, Fabian, Hauptstein, Sabine, Perera, Glen, Bernkop-Schnürch, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485494/
https://ncbi.nlm.nih.gov/pubmed/24095893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2013.09.017
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