eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

The discovery of an expanded (GGGGCC)n repeat (termed G4C2) within the first intron of C9orf72 in familial ALS/FTD has led to a number of studies showing that the aberrant expression of G4C2 RNA can produce toxic dipeptides through repeat-associated non-AUG (RAN-) translation. To reveal canonical tr...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Goodman, Lindsey D., Prudencio, Mercedes, Srinivasan, Ananth R., Rifai, Olivia M., Lee, Virginia M.-Y., Petrucelli, Leonard, Bonini, Nancy M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485101/
https://ncbi.nlm.nih.gov/pubmed/31023341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0711-9
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