Plasma exosomes exacerbate alcohol- and acetaminophen-induced toxicity via CYP2E1 pathway

Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytoch...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rahman, Mohammad A., Kodidela, Sunitha, Sinha, Namita, Haque, Sanjana, Shukla, Pradeep K., Rao, Radhakrishna, Kumar, Santosh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484097/
https://ncbi.nlm.nih.gov/pubmed/31024054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43064-2
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