Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute express...

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Detalles Bibliográficos
Publicado en:Hum Genet
Main Authors: Bien, Stephanie A., Su, Yu-Ru, Conti, David V., Harrison, Tabitha A., Qu, Conghui, Guo, Xingyi, Lu, Yingchang, Albanes, Demetrius, Auer, Paul L., Banbury, Barbara L., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Buchanan, Daniel D., Caan, Bette J., Campbell, Peter T., Carlson, Christopher S., Chan, Andrew T., Chang-Claude, Jenny, Chen, Sai, Connolly, Charles M., Easton, Douglas F., Feskens, Edith J. M., Gallinger, Steven, Giles, Graham G., Gunter, Marc J., Hampe, Jochen, Huyghe, Jeroen R., Hoffmeister, Michael, Hudson, Thomas J., Jacobs, Eric J., Jenkins, Mark A., Kampman, Ellen, Kang, Hyun Min, Kühn, Tilman, Küry, Sébastien, Lejbkowicz, Flavio, Le Marchand, Loic, Milne, Roger L., Li, Li, Li, Christopher I., Lindblom, Annika, Lindor, Noralane M., Martín, Vicente, McNeil, Caroline E., Melas, Marilena, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Pharaoh, Paul D. P., Potter, John D., Qu, Chenxu, Riboli, Elio, Rennert, Gad, Sala, Núria, Schafmayer, Clemens, Scacheri, Peter C., Schmit, Stephanie L., Severi, Gianluca, Slattery, Martha L., Smith, Joshua D., Trichopoulou, Antonia, Tumino, Rosario, Ulrich, Cornelia M., van Duijnhoven, Fränzel J. B., Van Guelpen, Bethany, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Abecasis, Goncalo R., Casey, Graham, Nickerson, Deborah A., Gruber, Stephen B., Hsu, Li, Zheng, Wei, Peters, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2019
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483948/
https://ncbi.nlm.nih.gov/pubmed/30820706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-019-01989-8
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