tRNA Methylation Is a Global Determinant of Bacterial Multi-Drug Resistance

Gram-negative bacteria are intrinsically resistant to drugs, due to their double-membrane envelope structure that acts as a permeability barrier and as an anchor for efflux pumps. Antibiotics are blocked and expelled from cells, and cannot reach high enough intracellular concentrations to exert a th...

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Udgivet i:Cell Syst
Main Authors: Masuda, Isao, Matsubara, Ryuma, Christian, Thomas, Rojas, Enrique R., Yadavalli, Srujana S., Zhang, Lisheng, Goulian, Mark, Foster, Leonard, Huang, Kerwyn Casey, Hou, Ya-Ming
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483872/
https://ncbi.nlm.nih.gov/pubmed/30981730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.03.008
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