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tRNA Methylation Is a Global Determinant of Bacterial Multi-Drug Resistance
Gram-negative bacteria are intrinsically resistant to drugs, due to their double-membrane envelope structure that acts as a permeability barrier and as an anchor for efflux pumps. Antibiotics are blocked and expelled from cells, and cannot reach high enough intracellular concentrations to exert a th...
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| Publicado no: | Cell Syst |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6483872/ https://ncbi.nlm.nih.gov/pubmed/30981730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.03.008 |
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