Stem cell–derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes

The autoantigen-specific Tregs from pluripotent stem cells (PSCs), i.e., PSC-Tregs, have the ability to suppress autoimmunity. PSC-Tregs can be programmed to be tissue associated and to infiltrate into local inflamed tissues to suppress autoimmune responses after adoptive transfer. Nevertheless, the...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Haque, Mohammad, Lei, Fengyang, Xiong, Xiaofang, Das, Jugal Kishore, Ren, Xingcong, Fang, Deyu, Salek-Ardakani, Shahram, Yang, Jin-Ming, Song, Jianxun
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483657/
https://ncbi.nlm.nih.gov/pubmed/30777937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126471
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