C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis

Chronic tubulointerstitial injury impacts the prognosis of focal segmental glomerulosclerosis (FSGS). We found that the level of versican V1 was increased in tubular cells of FSGS patients. Tubular cell–derived versican V1 induced proliferation and collagen synthesis by activating the CD44/Smad3 pat...

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Pubblicato in:JCI Insight
Autori principali: Han, Runhong, Hu, Shuai, Qin, Weisong, Shi, Jinsong, Hou, Qin, Wang, Xia, Xu, Xiaodong, Zhang, Minchao, Zeng, Caihong, Liu, Zhihong, Bao, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483651/
https://ncbi.nlm.nih.gov/pubmed/30944246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122912
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