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C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis
Chronic tubulointerstitial injury impacts the prognosis of focal segmental glomerulosclerosis (FSGS). We found that the level of versican V1 was increased in tubular cells of FSGS patients. Tubular cell–derived versican V1 induced proliferation and collagen synthesis by activating the CD44/Smad3 pat...
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| 發表在: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6483651/ https://ncbi.nlm.nih.gov/pubmed/30944246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122912 |
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