Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency()

The mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1(m/m); Per2(m/m) double mutations display a decrease in female fertility starting approximately at 20 weeks old, with significantly less pups born from 32 weeks old onwards. Hi...

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Detaylı Bibliyografya
Yayımlandı:Biol Reprod
Asıl Yazarlar: Zheng, Yating, Liu, Chao, Li, Yan, Jiang, Haijuan, Yang, Peixin, Tang, Jing, Xu, Ying, Wang, Han, He, Yulong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483055/
https://ncbi.nlm.nih.gov/pubmed/30452546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioy245
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