Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression

Oral T. gondii infection (30 cysts of 76K strain) induces acute lethal ileitis in sensitive C57BL/6 (B6) mice with increased expression of IL-33 and its receptor ST2 in the ileum. Here we show that IL-33 is involved in ileitis, since absence of IL-33R/ST2 attenuated neutrophilic inflammation and Th1...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ryffel, Bernhard, Huang, Feng, Robinet, Pauline, Panek, Corine, Couillin, Isabelle, Erard, François, Piotet, Julie, Le Bert, Marc, Mackowiak, Claire, Torres Arias, Marbel, Dimier-Poisson, Isabelle, Zheng, Song Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482336/
https://ncbi.nlm.nih.gov/pubmed/31057534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00702
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