The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease

Absence of the mouse cell surface receptor SLAMF3 in SLAMF3-/- mice suggested that this receptor negatively regulates B cell homeostasis by modulating activation thresholds of B cell subsets. Here, we examine whether anti-SLAMF3 affects both B and T cell subsets during immune responses to haptenated...

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Vydáno v:Front Immunol
Hlavní autoři: Wang, Ninghai, Yigit, Burcu, van der Poel, Cees E., Cuenca, Marta, Carroll, Michael C., Herzog, Roland W., Engel, Pablo, Terhorst, Cox
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482334/
https://ncbi.nlm.nih.gov/pubmed/31057553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00831
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