Glucagon reduces airway hyperreactivity, inflammation, and remodeling induced by ovalbumin

Glucagon has been shown to be beneficial as a treatment for bronchospasm in asthmatics. Here, we investigate if glucagon would prevent airway hyperreactivity (AHR), lung inflammation, and remodeling in a murine model of asthma. Glucagon (10 and 100 µg/Kg, i.n.) significantly prevented AHR and eosino...

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Udgivet i:Sci Rep
Main Authors: Insuela, Daniella B. R., Azevedo, Carolina T., Coutinho, Diego S., Magalhães, Nathalia S., Ferrero, Maximiliano R., Ferreira, Tatiana Paula T., Cascabulho, Cynthia M., Henriques-Pons, Andrea, Olsen, Priscilla C., Diaz, Bruno L., Silva, Patricia M. R., Cordeiro, Renato S. B., Martins, Marco A., Carvalho, Vinicius F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482309/
https://ncbi.nlm.nih.gov/pubmed/31019244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42981-6
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