Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation

The group I metabotropic glutamate (mGlu) receptor subtypes, mGlu1 and mGlu5, strongly regulate hippocampal synaptic plasticity. Both harbor PSD-95/discs-large/ZO-1 (PDZ) motifs at their extreme carboxyl terminals, which allow interaction with the PDZ domain of Tamalin, regulate the cell surface exp...

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Bibliographische Detailangaben
Veröffentlicht in:Front Synaptic Neurosci
Hauptverfasser: Neyman, Sergey, Braunewell, Karl-Heinz, O’Connell, Kara E., Dev, Kumlesh K., Manahan-Vaughan, Denise
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482240/
https://ncbi.nlm.nih.gov/pubmed/31057390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsyn.2019.00013
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