In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

Stabilisation of fragile oligonucleotides, typically small interfering RNA (siRNA), is one of the most critical issues for oligonucleotide therapeutics. Many previous studies encapsulated oligonucleotides into ~100-nm nanoparticles. However, such nanoparticles inevitably accumulate in liver and sple...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Watanabe, Sumiyo, Hayashi, Kotaro, Toh, Kazuko, Kim, Hyun Jin, Liu, Xueying, Chaya, Hiroyuki, Fukushima, Shigeto, Katsushima, Keisuke, Kondo, Yutaka, Uchida, Satoshi, Ogura, Satomi, Nomoto, Takahiro, Takemoto, Hiroyasu, Cabral, Horacio, Kinoh, Hiroaki, Tanaka, Hiroyoshi Y., Kano, Mitsunobu R., Matsumoto, Yu, Fukuhara, Hiroshi, Uchida, Shunya, Nangaku, Masaomi, Osada, Kensuke, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482185/
https://ncbi.nlm.nih.gov/pubmed/31019193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09856-w
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados