Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance defence against infection, take on ever greater significance. Ps...

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Udgivet i:PLoS Pathog
Main Authors: McHugh, Brian J., Wang, Rongling, Li, Hsin-Ni, Beaumont, Paula E., Kells, Rebekah, Stevens, Holly, Young, Lisa, Rossi, Adriano G., Gray, Robert D., Dorin, Julia R., Gwyer Findlay, Emily L., Brough, David, Davidson, Donald J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481867/
https://ncbi.nlm.nih.gov/pubmed/30978238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007694
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