Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice

Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised of the IL-12p35 subunit and the other subunit Epstein-Barr virus-induced gene 3 (EBI3), regulates the activity of CD4+ T cells and macrophages, thereby playing a critical role in inflammatory and autoimmune dis...

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Udgivet i:Mediators Inflamm
Main Authors: Huang, Ying, Hu, Haiying, Liu, Ling, Ye, Jing, Wang, Zhen, Que, Bin, Liu, Wenjing, Shi, Ying, Zeng, Tao, Shi, Lei, Ji, Qingwei, Chang, Chao, Lin, Yingzhong
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481022/
https://ncbi.nlm.nih.gov/pubmed/31093011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3152040
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