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The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury, hepatic inflammation, and fibrosis. Hepatic stellate cells (HSCs) and cancer-associated fibroblasts (CAFs) are key player...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Baglieri, Jacopo, Brenner, David A., Kisseleva, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479943/
https://ncbi.nlm.nih.gov/pubmed/30959975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20071723
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