Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)

Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing double-stranded RNA (dsRNA) produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eukaryotic initiation factor 2α (eIF2α), halting cellular translation. Many viruses ha...

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Publicat a:mBio
Autors principals: Goodman, Danielle E., Pretto, Carla D., Krepostman, Tomas A., Carnahan, Kelly E., Spindler, Katherine R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479006/
https://ncbi.nlm.nih.gov/pubmed/31015330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00668-19
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