LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer

Wnt/β-catenin and Hippo pathways play essential roles in the tumorigenesis and development of colorectal cancer. We found that Celastrol, isolated from Tripterygium wilfordii plant, exerted a significant inhibitory effect on colorectal cancer cell growth in vitro and in vivo, and further unraveled t...

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Detalhes bibliográficos
Publicado no:Ther Adv Med Oncol
Main Authors: Wang, Shuren, Ma, Kai, Zhou, Cuiqi, Wang, Yu, Hu, Guanghui, Chen, Lechuang, Li, Zhuo, Hu, Chenfei, Xu, Qing, Zhu, Hongxia, Liu, Mei, Xu, Ningzhi
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477772/
https://ncbi.nlm.nih.gov/pubmed/31040884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835919843736
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