MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY

ETMRs are aggressive embryonal brain tumors with a very poor prognosis, having a median overall survival of ~12 months after diagnosis. ETMRs harbour in ~90% of all cases amplification of a miRNA cluster on chromosome 19 (C19MC) that is thought to be the driver of the disease. However, current treat...

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Опубликовано в: :Neuro Oncol
Главные авторы: Lambo, Sander, Gröbner, Susanne, Rausch, Tobias, Waszak, Sebastian, Schmidt, Christin, Gorthi, Aparna, Romero, Carolina, Mauermann, Monika, Brabetz, Sebastian, Krausert, Sonja, Uro-Coste, Emmanuelle, Bourdeaut, Franck, Huang, Annie, Bishop, Alexander, Pfister, Stefan, Korshunov, Andrey, Kool, Marcel
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Medulloblastoma
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477396/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.170
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