EPEN-11. PROTEASOME AND HDAC INHIBITORS ARE CYTOTOXIC AGAINST RELA-FUSION PEDIATRIC EPENDYMOMA CELLS

Ependymomas are the third most common pediatric brain tumor. Nine ependymoma subgroups have been described based on tumor location and genetics. Of supratentorial ependymomas, the C11orf95-RELA fusion (ST-EPN-RELA) subgroup is the most aggressive. The RELA encoded protein is an NF-κB transcription f...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Campagna, Marissa, Ma, Xiangjuan, McCarl, Lauren, Kumar, Rajeev, Broniscer, Alberto, Agnihotri, Sameer, Felker, James, Pollack, Ian, Kohanbash, Gary
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Ependymoma
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477233/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.068
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