Trpm2 Ablation Accelerates Protein Aggregation by Impaired ADPR and Autophagic Clearance in the Brain

TRPM2 a cation channel is also known to work as an enzyme that hydrolyzes highly reactive, neurotoxic ADP-ribose (ADPR). Although ADPR is hydrolyzed by NUT9 pyrophosphatase in major organs, the enzyme is defective in the brain. The present study questions the role of TRPM2 in the catabolism of ADPR...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Jang, Yongwoo, Lee, Byeongjun, Kim, Hyungsup, Jung, Seungmoon, Lee, Sung Hoon, Lee, So-Young, Jeon, Ji Hyun, Kim, In-Beom, Lee, Seo-Ho, Kim, Byung-Ju, Kim, Uh-Hyun, Lee, Yunjong, Kim, Sung Min, Jeon, Daejong, Oh, Uhtaek
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477016/
https://ncbi.nlm.nih.gov/pubmed/30215158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1309-0
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