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Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption in amphibians

The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces available iodide for thyroid hormone synthesis, which leads to hormone insufficiency in tissues and subs...

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Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Olker, Jennifer H., Haselman, Jonathan T., Kosian, Patricia A., Donnay, Kelby G., Korte, Joseph J., Blanksma, Chad, Hornung, Michael W., Degitz, Sigmund J.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476556/
https://ncbi.nlm.nih.gov/pubmed/30137636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy203
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