Granulocyte Macrophage-Colony-stimulating Factor Autoantibodies and Increased Intestinal Permeability in Crohn Disease

BACKGROUND: Alterations in intestinal permeability have been implicated in the pathogenesis of Crohn disease (CD). We have reported that granulocyte macrophage-colony-stimulating factor (GM-csF) is required for mucosal barrier function in mice, and elevated neutralizing GM-CsF autoantibodies (Ab) ar...

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Published in:J Pediatr Gastroenterol Nutr
Main Authors: Nylund, Cade M., D’Mello, Sharon, Kim, Mi-ük, Bonkowski, Erin, Däbritz, Jan, Foell, Dirk, Meddings, Jon, Trapnell, Bruce C., Denson, Lee A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476427/
https://ncbi.nlm.nih.gov/pubmed/21502824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPG.0b013e3181fe2d93
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