The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection

Herpes simplex virus 1 (HSV-1) cycles between phases of latency in sensory neurons and replication in mucosal sites. HSV-1 encodes two key proteins that antagonize the shutdown of host translation, US11 through preventing PKR activation and ICP34.5 through mediating dephosphorylation of the α subuni...

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Vydáno v:J Virol
Hlavní autoři: Charron, Audra J., Ward, Stephen L., North, Brian J., Ceron, Stacey, Leib, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475787/
https://ncbi.nlm.nih.gov/pubmed/30760571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02246-18
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