Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts

As patient derived xenograft (PDX) models are increasingly used for preclinical drug development, strategies to account for the nonhuman component of PDX RNA expression data are critical to its interpretation. A bioinformatics pipeline to separate donor tumor and mouse stroma transcriptome profiles...

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Vydáno v:Sci Rep
Hlavní autoři: Liu, Yuanhang, Chanana, Pritha, Davila, Jaime I., Hou, Xiaonan, Zanfagnin, Valentina, McGehee, Cordelia D., Goode, Ellen L., Polley, Eric C., Haluska, Paul, Weroha, S. John, Wang, Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474864/
https://ncbi.nlm.nih.gov/pubmed/31004097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42680-2
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